HEMO Study was a randomized, controlled clinical trial that tested the role of high-flux membranes and high-efficiency dialysis on the morbidity and mortality of HD patients treated three times per week.
The results showed no major overall beneficial effects of an increase in dialysis dose above the currently recommended standard and no improvement in mortality with use of high-flux membranes in 1846 patients followed up to 6.5 years
Note, this study did not use convective systems which are present in HDF and theoretically large solute clearance not in consideration at all here .... a bit "kuno" lah in other words ....
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